Psychedelic plant rituals are part of humanity’s ancient relationship to nature. Other psychoactive plant species, such as tobacco, are partner to those rituals. Each of these can carry potential wisdom, healing, yet also shadows, depending on human factors. Learn about the botany, chemistry, and indigenous ceremonial histories of these few species, which all evolved in the Americas. Their stories are rich with symbolic meaning and shamanic healing methods. As living ethnobotany, this knowledge is always evolving. Now that psychedelic plants are being cultivated, globalized, and adopted into contemporary roles, their indigenous traditions are transformed, and sometimes lost. We will consider our relationships to these profound ‘plant teachers’ as they appear in 21st century culture.